Complete Genes for Complete Cures.

Kano Therapeutics is a founder-led biotech startup enabling safe, effective, and flexible correction of gene-length stretches of DNA through a new class of biomaterial: circular single-stranded DNA.

We aim to empower scientists, labs, and companies with the building blocks they need to cross the chasm to genetic cures.

We innovate around the message,
not the messenger.

We focus on optimized DNA donor material.

Single-stranded DNA (ssDNA) pairs the stability of double-stranded DNA and the flexibility of RNA to offer the best of both worlds in today’s therapeutic nucleic acids. Kano’s fermentation-based ssDNA production technique enables gene-length circular single-stranded DNA templates: a fundamentally better building block for genomic engineering.

  • Why use single-stranded DNA for gene insertion?
    • 01 Precise insertion: Published higher site-specific knock-in efficiencies and lower off-target insertion.
    • 02 Safe genome editing: Half the amount of DNA for same molar concentration, lower immune activation.
    • 03 Structural flexibility: ssDNA have local structure offering engineerable, functional 2D/3D features.
  • Doesn't CRISPR do this?

    CRISPR alone works well to cut and remove faulty genetic material, but to fully realize the potential of therapeutic gene editing we need complementary technology to insert long stretches of DNA site specifically.

    Our DNA donors complement CRISPR or any other gene editing tool used to insert synthetic genes.

  • How are you making ssDNA affordable?

    We use fermentation-based DNA production: a tried-and-true method for cost effective manufacturing at scale. Additionally, we’re building a first-of-its-kind databank linking ssDNA sequence design to activity, speeding up development timelines and saving time and money for our partners.

Funding

Let’s get
in touch
info@kanotherapeutics.com